A rigorous one-semester introduction to the organic chemical reactions of greatest biological importance, taught through the lens of metabolism. Covers organic mechanisms underlying fundamental enzyme-catalyzed reactions and quantitative analysis of enzyme kinetics and metabolic networks. For quantitatively-inclined students interested in biology, this course is an alternative to the standard two-semester organic chemistry sequence (CHM303/304). Does not replace CHM303/304 for Chemistry majors. Satisfies the organic chemistry requirement for Molecular Biology majors and provides appropriate preparation for subsequent studies in Biochemistry.